Geoff H Werstuck Selected Research

Glucosamine (Dona)

1/2018	Glycosphingolipids promote pro-atherogenic pathways in the pathogenesis of hyperglycemia-induced accelerated atherosclerosis.
1/2017	Glucosamine induces ER stress by disrupting lipid-linked oligosaccharide biosynthesis and N-linked protein glycosylation.
4/2014	Oral glucosamine sulfate supplementation does not induce endoplasmic reticulum stress or activate the unfolded protein response in circulating leukocytes of human subjects.
1/2012	The role of glucosamine-induced ER stress in diabetic atherogenesis.
11/2011	Glucosamine-supplementation promotes endoplasmic reticulum stress, hepatic steatosis and accelerated atherogenesis in apoE-/- mice.
9/2009	Evidence supporting a role for endoplasmic reticulum stress in the development of atherosclerosis in a hyperglycaemic mouse model.
1/2009	Valproate attenuates accelerated atherosclerosis in hyperglycemic apoE-deficient mice: evidence in support of a role for endoplasmic reticulum stress and glycogen synthase kinase-3 in lesion development and hepatic steatosis.
1/2006	Glucosamine-induced endoplasmic reticulum dysfunction is associated with accelerated atherosclerosis in a hyperglycemic mouse model.
1/2006	Mechanisms linking diabetes mellitus to the development of atherosclerosis: a role for endoplasmic reticulum stress and glycogen synthase kinase-3.

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Geoff H Werstuck Research Topics

Disease

28	Atherosclerosis 01/2022 - 08/2003
12	Hyperglycemia 01/2022 - 01/2006
10	Cardiovascular Diseases (Cardiovascular Disease) 09/2022 - 08/2003
7	Inflammation (Inflammations) 11/2021 - 07/2004
5	Diabetes Mellitus 07/2020 - 01/2005
4	Atherosclerotic Plaque (Atheroma) 11/2021 - 09/2009
4	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2021 - 04/2012
4	Hyperhomocysteinemia 01/2012 - 08/2003
2	Type 2 Diabetes Mellitus (MODY) 11/2021 - 07/2020
2	Myocardial Infarction 01/2018 - 01/2018
2	Dyslipidemias (Dyslipidemia) 01/2012 - 09/2009
1	Obesity 10/2021
1	Hypertension (High Blood Pressure) 01/2021
1	Body Weight (Weight, Body) 01/2021
1	Prostatic Neoplasms (Prostate Cancer) 01/2021
1	Insulin Resistance 01/2021
1	Abdominal Obesity 01/2021
1	Disease Progression 05/2018
1	Coronary Artery Disease (Coronary Atherosclerosis) 01/2018
1	Coronary Disease (Coronary Heart Disease) 01/2018
1	Myocardial Ischemia (Ischemic Heart Diseases) 01/2018
1	Transient Ischemic Attack 01/2018
1	Diabetes Complications 01/2017
1	Neoplasms (Cancer) 05/2015
1	Osteoarthritis 04/2014
1	Vascular Calcification 09/2012
1	Hyperlipidemias (Hyperlipidemia) 07/2008
1	Bipolar Disorder (Manic Depressive Psychosis) 08/2007
1	Epilepsy (Aura) 08/2007
1	Blindness (Hysterical Blindness) 01/2006
1	Renal Insufficiency (Renal Failure) 01/2006
1	Alzheimer Disease (Alzheimer's Disease) 01/2005
1	Parkinson Disease (Parkinson's Disease) 01/2005
1	Urinary Bladder Neoplasms (Bladder Cancer) 05/2003

Drug/Important Bio-Agent (IBA)

15	Apolipoproteins E (ApoE)IBA 09/2022 - 08/2003
11	LipidsIBA 11/2021 - 01/2005
9	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 01/2007
9	Glucosamine (Dona)IBA 01/2018 - 01/2006
7	ApolipoproteinsIBA 01/2020 - 07/2004
6	Streptozocin (Streptozotocin)FDA Link 01/2020 - 01/2006
5	Blood Glucose (Blood Sugar)IBA 11/2021 - 11/2011
5	Valproic Acid (Depakote)FDA LinkGeneric 11/2017 - 01/2009
4	Insulin (Novolin)FDA Link 01/2021 - 01/2007
4	Glycogen Synthase (Synthase I)IBA 05/2018 - 01/2006
4	Glycogen Synthase KinasesIBA 05/2015 - 01/2006
3	Estrogens (Estrogen)FDA Link 01/2022 - 07/2020
3	CholesterolIBA 11/2021 - 01/2012
3	Testosterone (Sustanon)FDA Link 10/2021 - 11/2014
3	LeptinIBA 01/2021 - 09/2012
3	Endoplasmic Reticulum Chaperone BiPIBA 04/2012 - 05/2003
2	Fatty Acids (Saturated Fatty Acids)IBA 11/2021 - 09/2009
2	acetyl- 2- naphthylalanyl- 3- chlorophenylalanyl- 1- oxohexadecyl- seryl- 4- aminophenylalanyl(hydroorotyl)- 4- aminophenylalanyl(carbamoyl)- leucyl- ILys- prolyl- alaninamide FDA Link 01/2021 - 11/2014
2	Triglycerides (Triacylglycerol)IBA 01/2021 - 01/2018
2	AndrogensIBA 01/2021 - 11/2014
2	4-phenylbutyric acid (Buphenyl)FDA Link 01/2020 - 11/2017
2	SphingolipidsIBA 01/2018 - 10/2016
2	GlycosphingolipidsIBA 01/2018 - 10/2016
2	Glycerophospholipids (Phosphoglycerides)IBA 01/2018 - 10/2016
2	LDL Receptors (LDL Receptor)IBA 05/2015 - 12/2014
2	Methionine (L-Methionine)FDA Link 01/2012 - 07/2008
2	HomocysteineIBA 01/2006 - 08/2003
1	Estradiol (Delestrogen)FDA LinkGeneric 01/2022
1	AMP-Activated Protein KinasesIBA 11/2021
1	Hydroxymethylglutaryl CoA Reductases (HMG CoA Reductase)IBA 11/2021
1	salicylsalicylic acid (salsalate)IBA 11/2021
1	SalicylatesIBA 11/2021
1	Acetyl-CoA CarboxylaseIBA 11/2021
1	ProdrugsIBA 11/2021
1	HDL LipoproteinsIBA 01/2021
1	C-PeptideIBA 01/2021
1	Retinaldehyde (Retinal)IBA 01/2020
1	Biomarkers (Surrogate Marker)IBA 01/2018
1	Cytidine Diphosphate (CDP)IBA 10/2016
1	DiglyceridesIBA 10/2016
1	phosphatidylethanolamineIBA 10/2016
1	Gonadal Steroid Hormones (Sex Hormones)IBA 01/2016
1	Transcription Factor CHOPIBA 11/2014
1	Follicle Stimulating Hormone (Follitropin)FDA Link 11/2014
1	Luteinizing Hormone (Lutropin)FDA LinkGeneric 11/2014
1	Leuprolide (Lupron)FDA LinkGeneric 11/2014
1	Gonadotropin-Releasing Hormone (GnRH)FDA Link 11/2014
1	Therapeutic UsesIBA 09/2013
1	Messenger RNA (mRNA)IBA 04/2012
1	Drinking WaterIBA 01/2012
1	HexosaminesIBA 03/2010
1	Glycogen Synthase Kinase 3IBA 01/2009
1	AcidsIBA 08/2007
1	Pharmaceutical PreparationsIBA 08/2007
1	Biological ProductsIBA 01/2006
1	NF-KappaB Inhibitor alphaIBA 07/2004
1	Thrombin FDA Link 05/2003

Therapy/Procedure

6	Therapeutics 01/2021 - 01/2012
3	Injections 01/2018 - 11/2011
2	Castration 09/2022 - 01/2021
2	Orchiectomy (Orchidectomy) 01/2021 - 11/2014
1	Ovariectomy (Oophorectomy) 01/2022
1	Glycemic Control 10/2021
1	Surgical Amputation (Amputations) 01/2006